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龔紘毅

 

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研究領域：分子遺傳學 (Molecular Genetics)、海洋生物技術 (Marine Biotechnology)、分子細胞生物學 (Molecular Cell Biology)
研究室：海洋分子遺傳暨生技研究室 (Marine Molecular Genetics and Biotechnology Laboratory)
Email：hygong@mail.ntou.edu.tw
電話：02-2462-2192 分機 5224
學歷：國防醫學院生命科學研究所博士 (Graduate Institute of Life Sciences, National Defense Medical Center, R.O.C.)
Refereed Papers
  1. YH Li, HY Chen, YW Li, SY Wu, W Liu, GH Lin, SY Hu, ZK Chang, HY Gong, CH Liao, KY Chiang, CW Huang, JL Wu* (2013) Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells. Scientific Reports 3: 1176. (SCI)
  2. HY Gong*, SH Wu, HY Chin, HJ Lin, CSN Tang, YH Li, JL Wu (2013) Mozambique tilapia short progranulin genes contribute to defense against bacterial pathogens. Fish and Shellfish Immunology.
  3. SH Huang*, KS Huang, CH Yu, HY Gong (2013) Metabolic profile analysis of a single developing zebrafish embryo via monitoring of oxygen consumption rates within a microfluidic device. Biomicrofluidics 7: 064107. (SCI)
  4. YD Wang, SJ Huang, HN Chou, WL Liao, HY Gong, J Y Chen (2014) Transcriptome analysis of the effect of Vibrio alginolyticus infection on the innate immunity-related complement pathway in Epinephelus coioides. BMC Genomics 15(1): 1102. (SCI)
  5. WJ Chung, CL Huang, HY Gong, TY Ou, JL Hsu, SY Hu (2015) Recombinant production of biologically active giant grouper (Epinephelus lanceolatus) growth hormone from inclusion bodies of Escherichia coli by fed-batch culture. Protein Expression and Purification 110C: 79-88. (SCI)
  6. CL Cheng, SJ Huang, CL Wu, HY Gong, CF Ken, SY Hu, JL Wu (2015) Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection. Journal of Biomedical Science 22: 103. (SCI)
  7. JK Lu, HY Chou, HY Gong, PP Chiou, CW Huang, LL Chen, JL Wu (2015) The marine aquaculture biotechnology status and its sustainability in Taiwan. Current Biotechnology 4(3): 311-318.
  8. HI Liu, PP Chiou, HY Gong, HY Chou (2015) Cloning of the major capsid protein (MCP) of grouper Iridovirus of Taiwan (TGIV) and preliminary evaluation of a recombinant MCP vaccine against TGIV. International Journal of Molecular Sciences 16: 28647–28656. (SCI)
  9. YY Chen, JC Chen, YH Kuo, YC Lin, YH Chang, HY Gong, CL Huang (2016) Lipopolysaccharide and β-1,3-glucan-binding protein (LGBP) bind to seaweed polysaccharides and activate the prophenoloxidase system in white shrimp Litopenaeus vannamei. Developmental and Comparative Immunology 55: 144-151. (SCI)
  10. CY Pan, YH Liu, HY Gong, JY Chen* (2017) Transcriptome analysis of the effect of polyunsaturated fatty acids against Vibrio vulnificus infection in Oreochromis niloticus. Fish & Shellfish Immunology 62: 153-163. (SCI)
  11. SJ Huang, CL Cheng, JR Chen, HY Gong, W Liu, JL Wu (2017). Inducible liver-specific overexpression of gankyrin in zebrafish results in spontaneous intrahepatic cholangiocarcinoma and hepatocellular carcinoma formation. Biochem Biophys Res Commun. 490: 1052-1058. (SCI)
  12. HY Gong*, SH Wu, CY Chen, CW Huang, JK Lu, HY Chou (2017) Complete genome sequence of Streptococcus iniae 89353, a virulent strain isolated from diseased tilapia in Taiwan. Genome Announcements 5: e01524-16.
  13. SH Wu, HJ Lin, WF Lin, JL Wu, HY Gong* (2018) A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & Shellfish Immunology 75: 74-90. (SCI)
  14. PY Chu, JH Kuan, CC Tun, TH Hsu, HY Gong, CH Lin, CW Huang* (2018) Establishment of a Database of Microsatellite Markers for the Yellowfin Seabream (Acanthopagrus latus) in the Coastal Sea of Taiwan. J. Fish. Soc. Taiwan 45(2): 59-64.
  15. TH Hsu, HT Lee, JY Chen, HY Gong, CW Huang* (2018) Development of microsatellite multiplex PCR assays for the black seabream (Acanthopagrus schlegelii). J. Fish. Soc. Taiwan 45(2): 65-75.
  16. SH Wu, HY Chou, PC Liu, JL Wu, HY Gong* (2019) Granulin peptide GRN-41 of Mozambique tilapia is a novel antimicrobial peptide against Vibrio species. Biochem Biophys Res Commun. 515: 706-711. (SCI)
  17. TH Hsu TH, CW Huang, HT Lee, YH Kuo, KM Liu, CH Lin, HY Gong* (2020) Population genetic analysis for stock enhancement of silver sea bream (Rhabdosargus sarba) in Taiwan. Fishes (revised)
  18. Wu SH, Lin HJ, Lin WF, Wu JL and Gong HY*. (2018). A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & Shellfish Immunology 75: 74-90.
  19. Hsu TH, Lee HT, Chen JY, Gong HY, Huang CW*. (2018). Development of microsatellite multiplex PCR assays for the black seabream (Acanthopagrus schlegelii). J. Fish. Soc. Taiwan 45(2): 65-75.
  20. Chu PY, Kuan JH, TunCC, Hsu TH, Gong HY, Lin CH, Huang CW*. (2018). Establishment of a Database of Microsatellite Markers for the Yellowfin Seabream (Acanthopagrus latus) in the Coastal Sea of Taiwan. J. Fish. Soc. Taiwan. 45(2): 59-64.
  21. Wu SH, Chou HY, Liu PC, Wu JL, and Gong HY*. (2019). Granulin peptide GRN-41 of Mozambique tilapia is a novel antimicrobial peptide against Vibrio species. Biochemical and Biophysical Research Communications 515: 706-711.
  22. Hsu TH, Huang CW, Lee HT, Kuo YH, Liu KM, Lin CH, Gong HY*. (2020). Population genetic analysis for stock enhancement of silver sea bream (Rhabdosargus sarba) in Taiwan. Fishes 5: 19.
  23. Chiang KY, Lin WC, Tsai TY, Lin CW, Huang SJ, Huang CY, Wu SH, Ken CF, Gong HY*, Chen JY*, Wu JL*. (2020). Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection. PLOS ONE 15(7): e0236601.
  24. Kadiene EU, Ouddane B, Gong HY, Kim MS, Lee JS, Pan YJ, Hwang JS*, Souissi S*. (2020). Differential gene expression profile of male and female copepods in response to cadmium exposure. Ecotoxicology and Environmental Safety 204: 111048.
Other Publications
  1. 龔紘毅*、陳鳴泉、吳金洌、黃士晉 (2014) 新穎肌肉增強子序列及其應用。2014台北國際發明暨技術交易展發明競賽生物技術類首獎-鉑金獎。台北國際發明暨技術交易展 2012-2014鉑金獎(Platinum Awards)專刊，p44。
  2. 龔紘毅 (2015) 粉紅螢光神仙魚-新穎肌肉增強子表現系統在海洋生技及生醫產業之應用。邁向頂尖大學計畫成果系列展3- 生技醫藥 關鍵未來成果手冊。p34-35。
  3. T.T. Chen, C.M. Lin, M.J. Chen, J.H. Lo, P.P. Chiou, H.Y. Gong, J.L. Wu, M.H.C. Chen, C. Yarish (2015). 13. Transgenic Technology in Marine Organisms. Springer Handbook of Marine Biotechnology. pp 387-412. Kim, Se-Kwon (Ed.). 1560p. ISBN: 978-3-642-53970-1.
  4. 龔紘毅*、胡紹揚、吳金洌 (2015) 基因轉殖螢光觀賞魚發展及其不孕技術開發。農業生技產業季刊 43：34-48。
  5. 黃章文、徐德華、龔紘毅 (2020) 吳郭魚（台灣鯛）基因體分子標記輔助選育技術之研發與應用。前瞻基因體學技術於農業領域之研發應用與展望。第110~125頁。王强生等作 ; 劉嚞睿, 蔡明哲主編. -- 初版. -- 臺北市 : 臺大動植物農業產業創新教學推動中心, 2020.02。ISBN：978-986-5452-17-9。

 

Patents & Technology Transfer
  1. 龔紘毅*、陳鳴泉、吳金洌、黃士晉。新穎肌肉增強子及其應用。中華民國發明專利，第I 234043號。專利權人：國立臺灣海洋大學。專利期間: 2013/7/21~ 2031/1/19。
  2. 龔紘毅*、陳鳴泉、吳金洌、黃士晉。肌肉增強子及其應用。中國發明專利，証書號第1369854號。專利號：ZL 201110221498.0。專利期間：2014/03/26~ 2031/08/02。
  3. 龔紘毅*。新穎肌肉專一性表現單元應用於建立基因轉殖螢光觀賞魚。技轉移轉「芝林企業有限公司」。五年非專屬授權（2012/04/16 ~2017/04/15）。
  4. 龔紘毅*。吳郭魚先天免疫調節胜肽OmGRN-41以增強魚類抗病存活率技術。先期技轉給「全興國際水產股份有限公司」。五年非專屬授權（2012/12/26 ~2017/12/25）。
  5. 龔紘毅*。顯微注射法建立基因轉殖螢光神仙魚品系及多轉基因插入位點鑑定技術。技術移轉「芝林生物科技股份有限公司」。五年非專屬授權（2014/02/11 ~2019/02/10）。
  6. 龔紘毅*、林仲彥。(2020)。抗病與成長性狀功能性基因標記資料庫。技術轉移「基育生物科技股份有限公司」。兩年非專屬授權 (2020/06/29 ~2022/06/28）。

 

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